New Risk-Based Approach for Veterinary Drug Residues Resulting from Carryover
11 May 2026
Executive Summary
Recent developments within the Codex Alimentarius framework, particularly during CCRVDF28, mark significant progress in addressing veterinary drug residues arising from unintended carryover in animal feed.
In recent years, this issue has gained prominence due to increasing detections reported through systems such as the RASFF, reflecting both the structural nature of crosscontamination and the improved sensitivity of analytical methods. These findings have, in some cases, led to regulatory actions and trade disruptions, particularly where no Codex MRLs are established, highlighting the risk of disproportionate measures and potential trade barriers.
In response, Codex is advancing a risk-based approach integrating Action Levels (ALs), the Residue Risk Score (RRS), and the Risk Management Decision Tool (RMDT). As part of this work, Action Levels have been proposed for eggs, notably 220 µg/kg for nicarbazin (DNC) and 100 µg/kg for lasalocid, to support the interpretation of residue findings associated with carryover.
This framework enables a more proportionate interpretation of analytical results, strengthening consumer protection while improving consistency and predictability in international trade.
For competent authorities responsible for food safety oversight, this approach provides practical guidance to interpret low-level residue detections in a risk-based manner, differentiate between carryover and potential misuse, avoid disproportionate regulatory actions and unnecessary trade restrictions, and support harmonized decision-making aligned with Codex principles. Further work is needed to expand the range of substances covered, refine exposure assessment methodologies, and strengthen the scientific basis of the approach through data collection and international collaboration.
